The Potential Side Effects of Ketorolac Tromethamine: What You Need to Know

Introduction to Ketorolac Tromethamine

Ketorolac Tromethamine, a powerful nonsteroidal anti-inflammatory drug (NSAID), is often prescribed for short-term pain relief after surgery or for severe, acute pain. While it's effective in reducing inflammation and providing analgesic effects, it's essential to be aware of the potential side effects associated with its use. In this article, we will discuss 10 key aspects of Ketorolac Tromethamine and its potential side effects, ensuring that you have a comprehensive understanding of the drug and can make informed decisions about your healthcare.

Gastrointestinal Side Effects

One of the most common potential side effects of Ketorolac Tromethamine is gastrointestinal issues. These can range from mild discomfort, such as nausea and indigestion, to more severe problems, including ulcers, bleeding, and perforation of the stomach or intestines. To minimize the risk of gastrointestinal side effects, it's crucial to take the medication as prescribed by your doctor, avoid taking it for extended periods, and inform your healthcare provider if you have a history of stomach ulcers or other gastrointestinal problems.

Cardiovascular Risks

NSAIDs, including Ketorolac Tromethamine, have been linked to an increased risk of cardiovascular complications, such as heart attack and stroke. The risk is higher for those with pre-existing cardiovascular disease or risk factors, like high blood pressure, high cholesterol, or diabetes. It's essential to discuss these risks with your doctor before starting the medication and to monitor your cardiovascular health closely while taking Ketorolac Tromethamine.

Effects on Kidney Function

Ketorolac Tromethamine can potentially affect kidney function, particularly in patients with pre-existing kidney problems or risk factors for kidney disease. Some of the signs of kidney issues include changes in urination, swelling in the legs or feet, and unexplained weight gain. If you experience any of these symptoms while taking Ketorolac Tromethamine, contact your healthcare provider immediately for evaluation and possible adjustment of your medication regimen.

Allergic Reactions

Some individuals may experience an allergic reaction to Ketorolac Tromethamine, which can present with symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. If you have a known allergy to other NSAIDs or aspirin, it's crucial to inform your doctor before taking Ketorolac Tromethamine. In the case of a severe allergic reaction, seek immediate medical attention.

Dizziness and Drowsiness

Feeling dizzy or drowsy is another potential side effect of Ketorolac Tromethamine. These symptoms can be mild or more severe, depending on the individual. To minimize the risk of dizziness and drowsiness, it's vital to take the medication as prescribed and avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the drug affects you.

Increased Bleeding Risk

Ketorolac Tromethamine may increase the risk of bleeding, especially in patients with a history of bleeding disorders or those taking other medications that can affect blood clotting. If you notice any unusual bruising, bleeding, or signs of anemia (such as fatigue or pale skin) while taking Ketorolac Tromethamine, contact your healthcare provider immediately for evaluation.

Interaction with Other Medications

It's essential to inform your healthcare provider about all the medications you are currently taking, as Ketorolac Tromethamine can potentially interact with several other drugs. Some examples of medications that may interact with Ketorolac Tromethamine include blood thinners, other NSAIDs, corticosteroids, and certain antidepressants. Your doctor may need to adjust your medication regimen to minimize the risk of potential interactions.

Pregnancy and Breastfeeding Considerations

Ketorolac Tromethamine is not recommended for use during pregnancy, particularly during the third trimester, as it may cause harm to the developing fetus. If you are pregnant or planning to become pregnant, discuss alternative pain relief options with your healthcare provider. Additionally, it's essential to inform your doctor if you are breastfeeding, as Ketorolac Tromethamine can pass into breast milk and may affect the nursing infant.

Overdose and Missed Doses

It's crucial to take Ketorolac Tromethamine as prescribed by your doctor to minimize the risk of overdose. Symptoms of an overdose may include severe drowsiness, vomiting, slow or shallow breathing, or seizures. If you suspect an overdose, seek immediate medical attention. In the case of a missed dose, take the medication as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for a missed one.


While Ketorolac Tromethamine can provide effective short-term pain relief, it's essential to be aware of the potential side effects associated with its use. By understanding these risks, discussing them with your healthcare provider, and closely monitoring your health while taking the medication, you can make informed decisions about your pain management and minimize the potential for adverse effects.